The gene responsible for pseudohypoparathyroidism type Ib is paternally imprinted and maps in four unrelated kindreds to chromosome 20q13.3.

نویسندگان

  • H Jüppner
  • E Schipani
  • M Bastepe
  • D E Cole
  • M L Lawson
  • M Mannstadt
  • G N Hendy
  • H Plotkin
  • H Koshiyama
  • T Koh
  • J D Crawford
  • B R Olsen
  • M Vikkula
چکیده

Hypocalcemia and hyperphosphatemia caused by parathyroid hormone (PTH)-resistance are the only discernible abnormalities in pseudohypoparathyroidism type Ib (PHP-Ib). Because mutations in the PTH/PTH-related peptide receptor, a plausible candidate gene, had been excluded previously, we conducted a genome-wide search with four PHP-Ib kindreds and established linkage to a small telomeric region on chromosome 20q, which contains the stimulatory G protein gene. We, furthermore, showed that the genetic defect is imprinted paternally and thus is inherited in the same mode as the PTH-resistant hypocalcemia in kindreds with PHP-Ia and/or pseudo-pseudohypoparathyroidism, two related disorders caused by different stimulatory G protein mutations.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 95 20  شماره 

صفحات  -

تاریخ انتشار 1998